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爆ぜろリアル!弾けろシナプス!パニッシュメントディスワールド!

个人简介 置顶

主要学习经历

  • 201109-201407 杭州育才中学
  • 201409-201707 杭州学军中学(保送)
  • 201709-202107 北京大学 化学与分子工程学院(降分预录取)
  • 202109- 北京大学 化学与分子工程学院 直博 - 唐淳老师课题组
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Protein Structure Mapping:Unveiling the Mechanism of Diazirine Photo-reactions

Original link: https://communities.springernature.com/posts/protein-structure-mapping-unveiling-the-mechanism-of-diazirine-photo-reactions

Diazirine, a functional group known for its three-membered ring that opens upon irradiation, has been widely used in photo-chemistry. Despite its broad application, the photo-reaction mechanisms of alkyl diazirines, especially their intermediate pathways and preferences towards protein residues, remained poorly understood. Addressing this knowledge gap was crucial for leveraging photo-cross-linking (PXL)’s full potential in protein structure analysis.
In our recent paper, “Dissecting Diazirine Photo-reaction Mechanism for Protein Residue-Specific Cross-linking and Distance Mapping“, published in Nature Communication, we delved into the intricate mechanisms of diazirine photo-reactions. Our goal was to accurately identify the photo-cross-linked protein residue for protein strucure mapping, which has long been accomplished with chemical cross-linkers.
Figure 1: Schematic of the diazirine photolysis mechanism intermediates and preferences towards protein residues.


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皖南春行:迢递宏村

宏村位于中国安徽省南部的黄山脚下,是一座有着大量明清时期历史建筑的古村落。村中还构建了完善的水系和颇具特色的“牛”形布局,是徽州民居的典型代表。2000年,包括宏村在内的皖南古村落在第24届世界遗产委员会上被列为世界文化遗产,并被《米其林旅游指南》评为“三星级旅游推荐”(最高级别)。

行到水穷处,坐看云起时;祖宗的诗画,亦是悠远的现实


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